Cholesterol 24-hydroxylase-IN-1( —— )

Catalog No. M35474 CAS No. 1613480-70-8

Cholesterol 24-hydroxylase-IN-1 is an orally active, selective, and potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) that crosses the blood-brain barrier.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Cholesterol 24-hydroxylase-IN-1
Note

Research use only, not for human use.
Brief Description

Cholesterol 24-hydroxylase-IN-1 is an orally active, selective, and potent inhibitor of cholesterol 24-hydroxylase (CH24H or CYP46A1) that crosses the blood-brain barrier.
Description

Cholesterol 24-hydroxylase-IN-1 (compound 17) is a potent, orally active, and highly selective cholesterol 24-hydroxylase (CH24H or CYP46A1) inhibitor (IC50=8.5 nM). Cholesterol 24-hydroxylase-IN-1 can cross blood-brain barrier.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Metabolic Enzyme/Protease
Target

P450
Recptor

P450
Research Area

——
Indication

——

Chemical Information

CAS Number

1613480-70-8
Formula Weight

313.4
Molecular Formula

C17H23N5O
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 100 mg/mL (319.08 mM; Ultrasonic (<60°C)
SMILES

O=C(N(C)C)C1CCN(C=2C=NC=CC2N3N=CC(=C3)C)CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kajita Y, et al. Discovery of Novel 3-Piperidinyl Pyridine Derivatives as Highly Potent and Selective Cholesterol 24-Hydroxylase (CH24H) Inhibitors. J Med Chem. 2022;65(4):3343-3358.?

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